Is Pregabalin (Lyrica) safe in kidney disease at eGFR <15?

CrCl <15 — 100% renal clearance means levels rise steeply. This table is dosing guidance for planning — the final dose is confirmed by your prescriber, and kidney function and the drug's own monitoring requirements are rechecked regularly.

What should I check while taking Pregabalin (Lyrica) at eGFR <15?

Follow the drug's label monitoring — typically kidney function (eGFR/creatinine), and for many drugs potassium, drug levels, or blood counts as applicable. Report any new symptoms such as weakness, irregular heartbeat, or unusual side effects to your doctor.

Is Pregabalin (Lyrica) safe in kidney disease at eGFR <15?

CrCl <15 — 100% renal clearance means levels rise steeply. This table is dosing guidance for planning — the final dose is confirmed by your prescriber, and kidney function and the drug's own monitoring requirements are rechecked regularly.

What should I check while taking Pregabalin (Lyrica) at eGFR <15?

Follow the drug's label monitoring — typically kidney function (eGFR/creatinine), and for many drugs potassium, drug levels, or blood counts as applicable. Report any new symptoms such as weakness, irregular heartbeat, or unusual side effects to your doctor.

Renal Dosing Guide

Pregabalin (Lyrica) Dosing at eGFR <15

Lyrica • Gabapentinoid (anticonvulsant) • Kidney function: <15 mL/min/1.73m² (not on dialysis)

The recommended dose of Pregabalin (Lyrica) at <15 mL/min/1.73m² (not on dialysis) — with monitoring notes for kidney disease and dialysis.

Recommended dose at eGFR <15

Max 75 mg/day.

CrCl <15 — 100% renal clearance means levels rise steeply.

Dosing at Other Kidney Function Levels

Pregabalin (Lyrica) at eGFR ≥45

≥45 mL/min/1.73m² (or CrCl >50)

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Pregabalin (Lyrica) at eGFR 30–44

30–44 mL/min/1.73m² (or CrCl 30–50)

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Pregabalin (Lyrica) at eGFR 15–29

15–29 mL/min/1.73m² (or CrCl 15–29)

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Pregabalin (Lyrica) at On dialysis

Hemodialysis or peritoneal dialysis

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How dosing is decided

Doses in this guide follow drug labels and renal-dosing references at each eGFR/CrCl level. Always confirm with your prescriber and pharmacy — your specific dose depends on other medications, conditions, and lab results.

Full Pregabalin (Lyrica) kidney guide

Monitoring reminder

Pregabalin (Lyrica) has its own monitoring requirements (eGFR, potassium, drug levels, or blood counts). These become more frequent as kidney function falls. Report unusual weakness, irregular heartbeat, or new side effects promptly.

Interactive drug-dosing tool