Is NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys safe in kidney disease at eGFR <15?

Not used below eGFR 15. This table is dosing guidance for planning — the final dose is confirmed by your prescriber, and kidney function and the drug's own monitoring requirements are rechecked regularly.

What should I check while taking NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys at eGFR <15?

Follow the drug's label monitoring — typically kidney function (eGFR/creatinine), and for many drugs potassium, drug levels, or blood counts as applicable. Report any new symptoms such as weakness, irregular heartbeat, or unusual side effects to your doctor.

Is NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys safe in kidney disease at eGFR <15?

Not used below eGFR 15. This table is dosing guidance for planning — the final dose is confirmed by your prescriber, and kidney function and the drug's own monitoring requirements are rechecked regularly.

What should I check while taking NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys at eGFR <15?

Follow the drug's label monitoring — typically kidney function (eGFR/creatinine), and for many drugs potassium, drug levels, or blood counts as applicable. Report any new symptoms such as weakness, irregular heartbeat, or unusual side effects to your doctor.

Renal Dosing Guide

NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys Dosing at eGFR <15

Advil / Voltaren / Aleve / Brufen • Nonsteroidal anti-inflammatory drugs • Kidney function: <15 mL/min/1.73m² (not on dialysis)

The recommended dose of NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys at <15 mL/min/1.73m² (not on dialysis) — with monitoring notes for kidney disease and dialysis.

Recommended dose at eGFR <15

Contraindicated.

Not used below eGFR 15.

Dosing at Other Kidney Function Levels

NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys at eGFR ≥45

≥45 mL/min/1.73m² (or CrCl >50)

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NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys at eGFR 30–44

30–44 mL/min/1.73m² (or CrCl 30–50)

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NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys at eGFR 15–29

15–29 mL/min/1.73m² (or CrCl 15–29)

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NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys at On dialysis

Hemodialysis or peritoneal dialysis

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How dosing is decided

Doses in this guide follow drug labels and renal-dosing references at each eGFR/CrCl level. Always confirm with your prescriber and pharmacy — your specific dose depends on other medications, conditions, and lab results.

Full NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys kidney guide

Monitoring reminder

NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys has its own monitoring requirements (eGFR, potassium, drug levels, or blood counts). These become more frequent as kidney function falls. Report unusual weakness, irregular heartbeat, or new side effects promptly.

Interactive drug-dosing tool

NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys at eGFR <15: FAQs

Renal Dosing Guide

NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys Dosing at eGFR <15

Advil / Voltaren / Aleve / Brufen • Nonsteroidal anti-inflammatory drugs • Kidney function: <15 mL/min/1.73m² (not on dialysis)

The recommended dose of NSAIDs (Ibuprofen, Diclofenac, Naproxen) and Kidneys at <15 mL/min/1.73m² (not on dialysis) — with monitoring notes for kidney disease and dialysis.